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A 2017 review exploring health-outcomes and complications linked to zero-calorie sweeteners concluded that not enough studies had been done to make a judgment about stevias overall safety. Artificial sweeteners are many times sweeter than sugar. Stevia (Pure Via, Truvia) Artificial sweeteners are also called sugar substitutes, low-calorie sweeteners or nonnutritive sweeteners. heartburn. https://www.who.int/publications/i/item/9789240046429. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. The impact of nonnutritive sweetener on an individuals health may depend on the amount that is consumed, as well as the time of day its consumed. (2013). Though research on this issue is limited, it's possible that stevia may have an effect on the endocrine system, which includes glands that produce hormones. A study published in December 2015 in Physiology & Behavior notes that certain non-nutritive sweeteners have been linked to a reduction in dental cavities. View abstract. U.S. Food and Drug Administration. Stevia has a slightly bitter flavor that some people don't like. Accessed Nov. 14, 2022. Avicenna J Phytomed. Some stevia side effects include digestive or stomach issues, allergies, an increased risk of weight gain and potential endocrine disruption. Learn about the pros and cons of sugar substitutes, also called artificial sweeteners. However, stevia's safety and potential side effects have generated controversy. Monitor your blood pressure closely. And finally, the study says that stevia in addition to a regular drug regimen could reduce the progression of chronic kidney disease (CKD). Can diet help improve depression symptoms? Whole foods, such as fruits and vegetables, usually have the best mix of nutrients for the body. Metabolism 2004;53(10):1378-1381. However, more research needs to be done to provide conclusive evidence on weight management, diabetes and other health issues. Purified stevia leaf extracts (Truvia, PureVia, others). Centers for Disease Control and Prevention. feeling of constant movement of self or surroundings. Therapeutic Research Faculty 2020. For adults and children with overweight or obesity, sugar substitutes also might help manage weight in the short term. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. J Ethnopharmacol 1991;33:257-622. In general, experts need to do more studies to learn what long-term health effects sugar substitutes might have on children. 2016;2016:5967907. View abstract. Accessed Nov. 11, 2022. Tooth decay occurs when bacteria from sugar damage the teeth. Sucralose. Taware, A. S., Mukadam, D. S., and Chavan, A. M. Antimicrobial Activity of Different Extracts of Callus and Tissue Cultured Plantlets of Stevia Rebaudiana (Bertoni). Mayo Clinic does not endorse companies or products. Melis MS, Sainati AR. 1-15-2009;17(2):600-605. Last medically reviewed on October 27, 2017. Anton SD, et al. High doses or heavy, long-term use of stevia may worsen common pregnancy symptoms by increasing the workload on organs such as the kidneys, bladder, and heart. Chen, T. H., Chen, S. C., Chan, P., Chu, Y. L., Yang, H. Y., and Cheng, J. T. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. (2013). World Health Organization, Food and Agriculture Organization of the United Nations. Food Chem Toxicol 2008;46 Suppl 7:S75-82. View abstract. MNT is the registered trade mark of Healthline Media. Are the benefits of Stevia better than sugar? 1984;47(3):439-444. Remember that stevia is much sweeter than table sugar, so you wont need to use as much. It's about 100 to 300 times sweeter than table sugar, but it has no carbohydrates, calories, or artificial ingredients.. Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines [Abstract]. Has stevia been approved by FDA to be used as a sweetener? They're different in the United States and Europe, for example. 2016;22(1):7-17. Psychological Effects Sugar, particularly refined sugars, has been linked to countless health risks, including diabetes and heart disease. View abstract. Nat.Prod Res 2009;23(15):1378-1383. Chan P, Xu DY, Liu JC, et al. Forms include: Stevia is much sweeter than sugar and may be up to 250300 times sweeter than sucrose, the molecule in table sugar. Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats. Steviol glycosides are natural constituents of the leaves of Stevia rebaudiana (Bertoni) Bertoni, a plant native to parts of South America and commonly known as Stevia. The FDA considers stevia and its compounds steviol glycosides safe, deeming it "generally recognized as safe" (GRAS). Potential side effects linked to stevia consumption include: Stevia is considered a diuretic, meaning that it increases the speed at which the body expels water and electrolytes from the body in urine. Accessed Nov. 15, 2022. DOI: Zeratsky K. (2018). Saudi Pharmaceutical Journal. mood swings Read more The 5 Best (and Worst) Sweeteners You Can Eat - Cleveland Clinic Until research determines whether whole-leaf stevia is safe for everyone, get your doctors approval before using it regularly, especially if you have a serious medical condition such as diabetes, heart disease, or high blood pressure. View abstract. 2002;25(11):1488-1490. New research shows that artificial sweeteners may increase the risk of weight gain and, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Over time, it's most important to eat a healthy diet and get exercise. DOI: Ukiya M, et al. Braz J Med Biol Res 1996;29:669-75. Some studies suggest it may have anti-inflammatory properties, though more research is needed to determine the magnitude of this effect. Stevia side effects. Video of the Day The Science Behind Stevia Stevia, not to be confused with Splenda, is a sugar substitute sweetener that comes from the plant Stevia rebaudiana, which is native to South America. Many argue that this means theres nothing natural about them. Phytochemistry 2003;64:913-21. Ajami M, Seyfi M, Abdollah Pouri Hosseini F, et al. DOI: Pepino MY. Ive heard its good for weight control. 2003;41(3):359-374. Artificial sweeteners and other sugar substitutes. That means a can of sweetened cola with 10 teaspoons of added sugar has about 160 calories. https://www.cdc.gov/healthyweight/healthy_eating/sugar.html. And while the study published in December 2015 in Physiology & Behavior also investigated whether stevia can impair gut flora in the digestive tract, more research is needed to solidify the link. This amount is called the acceptable daily intake (ADI). Matsui M, Matsui K, Kawasaki Y, et al. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. U.S. Food and Drug Administration, December 2008. View abstract. Stamataki NS, Crooks B, Ahmed A, McLaughlin JT. View abstract. J Nutr. stomach discomfort or upset. Monk Fruit vs. Stevia: Which Sweetener Should You Use? Some stevia products contain added sugar alcohols that may cause unpleasant symptoms in individuals that are very sensitive to the chemicals. Food Chem Toxicol 2008;46 Suppl 7:S40-6. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Our website services, content, and products are for informational purposes only. This site complies with the HONcode standard for trustworthy health information: verify here. 2007;232(1):164-173. From wellcurve.in. (2015). Curi R, Alvarez M, Bazotte RB, et al. (n.d.). 2017;41(3):450-457. Reb-A sweeteners are available in liquid, powder, and granulated forms. Stevia sweeteners don't have calories and are a good choice for people trying to lose weight. Agency Response Letter: GRAS Notice No. Hives. information submitted for this request. Stevia contains zero calories and carbohydrates, while sugar contains 15 calories and 4 carbohydrates per teaspoon. 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Researchers are checking to see if sugar substitutes affect cravings for sweets, the way people feel hunger and how the body manages blood sugar. Klongpanichpak, S., Temcharoen, P., Toskulkao, C., Apibal, S., and Glinsukon, T. Lack of mutagenicity of stevioside and steviol in Salmonella typhimurium TA 98 and TA 100. The amount of sugar alcohol that causes these symptoms varies from person to person. 2012;132(3):1121-1132. Takasaki, M., Konoshima, T., Kozuka, M., Tokuda, H., Takayasu, J., Nishino, H., Miyakoshi, M., Mizutani, K., and Lee, K. H. Cancer preventive agents. View abstract. https://www.fda.gov/food/food-additives-petitions/high-intensity-sweeteners. There are 11 steviol glycosides in the stevia leaf, responsible for giving stevia its sweet flavor. However, some of the common counterfeit ingredients found in stevia mixtures and formulas are linked to serious complications and may cause birth abnormalities. This means it has almost no calories. Whole-leaf stevia and crude stevia extract, including stevia youve grown at home, are not safe to use if youre pregnant. Stevia products found on grocery store shelves, such as Truvia and Stevia in the Raw, dont contain whole stevia leaf. Accessed Nov. 11, 2022. A study published in June 2019 in Proceedings of the National Academy of Sciences of the United States of America delved into how and why this plant naturally creates such a high level of sweetness. We avoid using tertiary references. Since then, research has shown that those findings don't apply to people. The hidden hazardous effects of Stevia and sucralose consumption in male and female albino mice in comparison to sucrose. It is based on significant research. Stevia leaf extracts side effects. Stevia, also called Stevia rebaudiana, is a plant that is a member of the chrysanthemum family, a subgroup of the Asteraceae family (ragweed family). Stevia may affect the transmission of nerve impulses to and from your central nervous system and may slow down nerve conduction velocity. Stevia is known to act as a vasodilator, causing the blood vessels to widen and lowering overall blood pressure. Pope E, Koren G, Bozzo P. Sugar substitutes during pregnancy. A 2013 study carried out in a laboratory found that stevia reduced cyst growth in kidney cells. DOI: Has stevia been approved by FDA to be used as a sweetener? Common potentially harmful chemicals found in stevia products include: When consumed at low doses, purified stevia is generally not considered to pose health risks for pregnant people. Some other potential side effects of stevia include allergic reactions. Sugar substitutes also are not linked to a higher risk of cancer in people. Can poor sleep impact your weight loss goals? According to the FDA, the acceptable daily intake for steviol equivalents is 4 milligrams (mg) per kilogram of body weight. A new study reveals the mechanisms behind, Millions of people routinely consume artificial sweeteners. Since Stevia helps to reduce high blood pressure, it can also low down the blood pressure when consumed on a regular basis. Anything that actively lowers blood pressure can cause health complications with excessive, long-term use. DOI: Azad MB, et al. Barriocanal LA, Palacios M, Benitez G, et al. Influence of stevioside on hepatic glycogen levels in fasted rats. A 2020 study found that people with type 2 diabetes who drank 1 cup of stevia-sweetened tea per day for 8 weeks had no significant changes in their blood glucose levels. For A 150-pound person, this would amount to around 40 packets of stevia. But if you use it throughout the day, the carbs add up. All rights reserved. The following are few of the asserted side effects or dangers of stevia: 1. Wasuntarawat C, Temcharoen P, Toskulkao C, et al. Can You Get Diabetes From Eating Too Much Sugar? Ac., CYT, 12 Benefits of Ginkgo Biloba (Plus Side Effects & Dosage). Pezzuto JM, Compadre CM, Swanson SM, et al. Theyre made from a highly refined stevia leaf extract called rebaudioside A (Reb-A). Despite this, stevia contains no calories or carbohydrates, compared to sugar which has 15 calories and 4 grams of carbohydrates per teaspoon. Some claim that it's entirely harmless, but new studies suggest that it may have some effects on your metabolism. A 2016 study found that human sperm cells exposed to steviol experienced an increase in progesterone production. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. You might try to stay away from table sugar by using less processed sweeteners such as honey and molasses. To avoid stevia stomach upset, be careful before purchasing stevia products. We dig into the ingredients of popular zero-regret ice creams and find out if our bodies can take the hype. However, as the research on stevia itself is limited, it's safe to say that incorporating this natural sweetener into your diet as a sugar substitute will likely yield greater benefits than risks. Swithers SE. They taste sweet like sugar but have fewer calories. However, some studies suggest that consuming nonnutritive sweeteners such as Stevia instead of sugar does not reduce overall calorie intake or blood sugar levels. Gardana, C., Simonetti, P., Canzi, E., Zanchi, R., and Pietta, P. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. A 2019 study reported a possible link between nonnutritive sweeteners, including stevia, and disruption in beneficial intestinal flora. fda.gov/aboutfda/transparency/basics/ucm194320.htm, fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/LabelingNutrition/ucm456090.htm, ncbi.nlm.nih.gov/pmc/articles/PMC6627124/, diabetes.org/food-and-fitness/food/what-can-i-eat/understanding-carbohydrates/artificial-sweeteners/not-completely-carbohydrate.html, krepublishers.com/02-Journals/S-EM/EM-03-0-000-09-Web/EM-03-2-000-2009-Abst-PDF/EM-03-2-137-09-047-Sharma-N/EM-03-2-137-09-047-Sharma-N-Tt.pdf, mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/stevia/faq-20057856. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Foods and drinks with aspartame can lead to serious health problems. Another popular zero-calorie sweetener issucralose, sold under the brand name Splenda. That includes soft drinks, candy and baked goods. It also may raise your risk of serious health problems, such as diabetes and heart disease. Geuns, J. M., Buyse, J., Vankeirsbilck, A., and Temme, E. H. Metabolism of stevioside by healthy subjects. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Clin Ther 2003;25:2797-808. One of the highly touted benefits of artificial sweeteners is that they have v irtually no calories. Braz J Med Biol Res 1986;19:771-4. Prakash I, Dubois GE, Clos JF, et al. And it may also interact with drugs like lithium. indigestion. Stevia Beverage Consumption prior to Lunch Reduces Appetite and Total Energy Intake without Affecting Glycemia or Attentional Bias to Food Cues: A Double-Blind Randomized Controlled Trial in Healthy Adults. People who may be more likely to experience side effects from stevia include people taking medications to lower blood pressure or blood glucose or those diagnosed with: Stevia leaf extract is safe to consume when pregnant or breastfeeding. Rios-Leyvraz M, et al. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. So, practice caution. Grembecka, M. (2015). Guilt-Free Ice Cream Is Trending, but Is It Actually Healthy? However, studies suggest that consuming sugar substitutes such as stevia in place of sugar does not have an impact on overall daily calories intake or blood sugar levels. Some research suggests stevia could make you gain weight. 4. A pinch of stevia powder is equal to about one teaspoon of table sugar. In general, it is safest to take in small amounts of sugar substitutes. This side effect might. Dextrose is glucose, and maltodextrin is a starch. It can be hard to know what foods are healthy, with so many options available today, but following a balanced diet and enjoying sugar and other sweeteners in moderation is the best way to keep your body healthy while still enjoying the foods you love. (2017). View abstract. Accessed Nov. 14, 2022. A single copy of these materials may be reprinted for noncommercial personal use only. https://professional.diabetes.org/sites/professional.diabetes.org/files/pel/source/sugar_substitutes.pdf. You can grow stevia plants at home and use the leaves to sweeten foods and beverages. In fact, many stevia products have very little stevia in them at all. Acesulfame potassium (Sweet One, Sunett). Geuns JM. Automatic detention of stevia leaves, extract of stevia leaves, and food containing stevia. Stevia can also interact with certain medications, so it is important to discuss stevia with a doctor before consuming or purchasing the product. These can be added to foods or drinks at home. And according to a 2009 study, stevia leaf powder may help manage cholesterol. However, whole stevia leaf is not approved by the FDA and is not generally recognized as safe for consumption by anyone, especially pregnant people. https://www.uptodate.com/contents/search. Mayo Clinic. Nutrients. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Some research on long-term, daily use of artificial sweeteners suggests a link to a higher risk of stroke, heart disease and death overall. The amount of sugar alcohol that causes these symptoms varies from person to person. You can learn more about how we ensure our content is accurate and current by reading our. https://www.mayoclinic.org/healthy-lifestyle/weight-loss/basics/weightloss-basics/hlv-20049483. If you are a Mayo Clinic patient, this could Though research on the long-term effects of stevia is limited, there is no evidence that it causes cancer. AlDeeb OA, Mahgoub H, Foda NH. Some people use products called sugar substitutes, also known as artificial sweeteners. You can bake with stevia, although it may give cakes and cookies a licorice aftertaste. Boonkaewwan, C., Toskulkao, C., and Vongsakul, M. Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. Your lithium dose might need to be changed. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. U.S. Food and Drug Administration. Liver side effects: Research on the impact of stevia on the liver is preliminary and . A review on the improvement of stevia [Stevia rebaudiana (Bertoni). Hsieh MH, Chan P, Sue YM, et al. However, there still isn't enough evidence or medical consensus on the benefits of stevia, and its side effects are still being explored. Currently, researchers have only explored the potentially positive aspects of this use. Food Chem Toxicol 2008;46 Suppl 7:S83-91. They generally don't raise blood sugar levels, so they're a good sugar alternative for people . People with allergies to ragweed, chrysanthemums, marigolds or daisies should be careful when trying stevia, according to Tufts Medical Center Community Care. However, some people have reported negative side effects, which include: Nausea Bloating Dizziness Numbness Muscle pain Abdominal fullness Allergic reactions such as rashes Hypotension (low blood pressure) Factors that may increase the risk of stevia side effects include: There are many different types of steviol glycoside found in stevia, classified into five major groups. Nutrients. Check with your physician for additional information about side effects. In addition to some of stevia's touted benefits as a sugar substitute in helping people lose weight or improve diabetes management, it has been linked to a number of other potential health benefits, though these are still being explored further. But because stevia is noncaloric, it's often used as a sugar substitute, especially for people hoping to manage diabetes or obesity. Muscle Pain Aching muscles may also occur in some cases as a reaction to this sweetener. Many people choose to replace sugar with stevia to reduce their calorie consumption. Effects of stevia on glycemic and lipid profile of type 2 diabetic patients: A randomized controlled trial. Development of rebiana, a natural, non-caloric sweetener. Two minor diterpene glycosides from the leaves of Stevia rebaudiana. They are non-nutritive. Though they're rare, stevia's side effects can include gastrointestinal symptoms, decreased blood pressure and blood sugar, and potential impacts on the liver. Stevia use has been shown to help limit and reduce diarrhea and the symptoms of irritable bowel syndrome (IBS). Additional information about high-intensity sweeteners. Phenylketonuria (PKU). View abstract. Some people enjoy it, but its a turn-off for others. Stevia does not cause side effects in most people. Read our. Currently, there isnt enough evidence that whole-leaf stevia or crude stevia extract wont harm your pregnancy. Metabolic effects of non-nutritive sweeteners. It's possible this is because people who consume a lot of sweet food or drinks in general even those with NSSs experience a greater craving for sweeter and unhealthy foods. Jeppesen, P. B., Gregersen, S., Alstrup, K. K., and Hermansen, K. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. For purposes of this article, stevia refers to Reb-A products. People thought that artificial sweeteners wouldn't have the same effect. Some stevia brands, such as Stevia in the Raw, can replace table sugar teaspoon for teaspoon (as in sweetened beverages and sauces), unless youre using it in baked goods. Stevia During Pregnancy and Breastfeeding. The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure. Most studies have looked at the effects in adults. J Agric Food Chem 2008;56:3777-84. Part 8: Chemopreventive effects of stevioside and related compounds. GRAS Notices Received in 2008. swelling. Although most of the existing research concerns the two major compounds in stevia stevioside and rebaudioside A (reb A) a 2016 study using human fecal samples concluded that all forms of the compound are probably safe for general use. It is many times sweeter than sugar yet has virtually zero calories. As a type of steroid, steviol glycosides can interfere with hormones controlled by the endocrine system. However, the FDA reversed the ban in 1995 after a follow-up study found no connection. If you're living with a rare genetic disease called phenylketonuria. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Verywell Health's content is for informational and educational purposes only. Studies using rat embryos have established that stevia did not affect pregnancy or fertility outcomes and was non-toxic to fetal tissues. Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. View abstract. Profiles Drug Subst Excip Relat Methodol. Advertisements 3. Processed foods often contain a lot of sugar, yet it can be difficult to tell how much. Both the FDA and European Commission concluded that the number of individuals who are hypersensitive to stevia or at a risk of having an allergic response to it is low. While adding a raw stevia leaf to a cup of tea now and then is unlikely to cause harm, you shouldnt use it if youre pregnant. EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, et al. View abstract. Available at: https://www.cfsan.fda.gov/~rdb/opa-gn08.html. All rights reserved. US Food and Drug Administration. Ray J, Kumar S, Laor D, et al. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Available Health Products from Mayo Clinic Store, Book: Mayo Clinic Family Health Book, 5th Edition, Book: Mayo Clinic 5 Steps to Controlling High Blood Pressure, Newsletter: Mayo Clinic Health Letter Digital Edition, Autism spectrum disorder and digestive symptoms, Bad food habits at work? In general, sugar substitutes are safe for healthy adults. Select a condition to view a list of vitamins. Sweeteners made with Reb-A are considered novel sweeteners because theyre blended with different sweeteners, such as erythritol (a sugar alcohol) and dextrose (glucose). A 2013 study supported these findings. It may take some trial and error to get the texture and level of sweetness you like. FDA. https://www.uptodate.com/contents/search. Sucralose is derived from sugar in a chemical process and is 400700 times sweeter than sugar. But limit or cut out sugar substitutes: Dietary guidelines for Americans say adults shouldn't give sugar substitutes to children under 2 years old. Yang, P. S., Lee, J. J., Tsao, C. W., Wu, H. T., and Cheng, J. T. Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. Stevia stomach upset, however, may be a cause for concern. This content does not have an English version. Int J Dent. It also left study participants satisfied and full after eating, despite the lower calorie intake. Artificial sweeteners and cancer. Stevioside. Life Sci 1998;63:1679-84. The most notable of these ingredients is saccharin. Is the ketogenic diet right for autoimmune conditions? These ingredients add small amounts of carbs and calories. Stevia products made with Reb-A are considered safe, even for people who are pregnant or who have diabetes. stevia leaf extract (greater than 95% steviol glycosides) was determined to be generally recognized as safe in 2008 by the FDA. 000252. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Some stevia side effects include potentially making it harder to lose weight. Stevia products made with sugar alcohols can also cause bloating, diarrhea and other stomach troubles for some people. However, since stevia can have blood pressure and blood glucoselowering effects, as well as diuretic effects, those taking certain medications or who have certain health conditions should talk with their healthcare provider before consuming significant quantities of Stevia. 5 Best Sugar Substitutes for People with Diabetes, Diet Drinks Won't Protect Heart Health Any Better Than Sugary Drinks: Study, Study: Raw Honey May Improve Blood Sugar and Cholesterol Levels, Stevia, Nature's Zero-Calorie Sustainable Sweetener: A New Player in the Fight Against Obesity, Additional information about high-intensity sweeteners, Effects of aspartame-, monk fruit-, stevia- and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake, Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice, Health outcomes of non-nutritive sweeteners: analysis of the research landscape, Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Health-Care Professionals, Low-Dose Stevia (Rebaudioside A) Consumption Perturbs Gut Microbiota and the Mesolimbic Dopamine Reward System, he hidden hazardous effects of Stevia and sucralose consumption in male and female albino mice in comparison to sucrose, Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis, FDA regulatory approach to steviol glycosides. Other side effects not listed may also occur in some patients. The agency doesn't consider sugar alcohols to be food additives. All rights reserved. How Does Stevia Compare to Other Zero-Calorie Sweeteners? Stevia is a sugar substitute made from the leaves of the stevia plant. You can learn more about how we ensure our content is accurate and current by reading our.